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NextGen Therapeutics

Merus's Preclinical Bispecific Zeno Demonstrates Efficacy in Cancer Models

Zeno interrupts the dimerization of HER2 and HER3 and prevents NRG1/HER3 tumour signalling.
Drug Discovery & Development

Positive Results from iNKT Cell Therapy Clinical Trial for COVID-19 ARDS

The small exploratory trial shows signs that iNKT cells can improve the survival rate of respiratory distress from COVID-19.
Cell Line Development

UNIVERCell: Engineering Red Blood Cells for Targeted Therapy

Scarlet Therapeutics uses genetic manipulation of red blood cells to carry a higher load of therapeutic proteins to help treat rare metabolic diseases.
Cell Line Development

Enhancing Gene Editing Efficiency: Multi-Tailed mRNA Integration in CRISPR-Cas9 Systems

A study conducted by the Broad Institute and the Massachusetts Institute of Technology (MIT) demonstrated that when multi-tailed mRNAs were integrated into a CRISPR-Cas9 system they proved to be more efficient gene editors than unmodified mRNA.
Oligo Chemistry

Japanese Team Successfully Skip Abnormal Gene In Vitro With Antisense Oligonucleotide for BPAN

Rare disease BPAN currently has no treatment options, this new research investigates whether antisense oligonucleotide therapies could be the answer to address this unmet need.
Oligo Chemistry

Oligo Sequencing Technologies - What Methods and Techniques Are Utilized in the Pharmaceutical Industry?

Oligo sequencing revolutionizes biologics research, ensuring accurate analysis of oligonucleotides. Biologics by Oxford Global explores methods, safety, sustainability, and future trends. Despite challenges, advancements promise exciting opportunities for scientific discovery.
Drug Discovery & Development

How to Improve Therapeutic Efficacy: Safety Considerations in Oncolytic Virotherapy

Oncolytic virotherapy targets cancer cells with viruses, promising personalized treatment with minimal side effects. Safety measures include minimizing off-target effects and systemic spread. Combining with immunotherapy enhances efficacy, revolutionizing cancer treatment.
Drug Discovery & Development

Zika Virus Tested as an Effective Oncolytic Agent for Glioblastoma in In Vitro Models

More results are in for the oncolytic potential of the Zika virus, where it has proven effective against the most common form of brain cancer in vitro.
Oligo Chemistry

Innovation at the Crossroads: Oligonucleotide Therapeutics and the Evolution of Drug Design

Can oligonucleotide therapeutics shape the future of healthcare? We journey through AI frontiers, sustainable synthesis, and regulatory challenges.

Cell Therapy for Solid Tumors: An Innovative Approach to Cancer Treatment

Cell therapy for solid tumours is an innovative cancer treatment that uses a patient's own immune cells or donor cells to fight cancer, but its effectiveness varies by tumour type and patient's immune system. Although it offers new hope, it poses risks such as cytokine release syndrome and neurotoxicity. Recent advancements have led to better targeting, combination therapies, and next-generation treatments, with future research aimed at improving safety, effectiveness, and accessibility, potentially revolutionising cancer care.
Gene Therapy Development

Post-Event Proceedings – Gene Therapy Development & Manufacturing 2023

Concise and insightful summaries of presentations delivered by prominent thought leaders at Gene Therapy Development & Manufacturing 2023.
Drug Discovery & Development

Post-Event Proceedings – Immuno 2023

Concise and insightful summaries of presentations delivered by prominent thought leaders at Immuno 2023.

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