Analytical and Chemical Enhancements to Improve Efficacy and Accuracy of Therapeutic Oligonucleotides

Oligonucleotide therapeutics represent a rapidly growing and increasingly powerful class of drugs. By interfering with the production of proteins linked to diseases, for example by blocking the production of harmful proteins, or by increasing the production of helpful proteins, they can go straight to the source of a morbidity.

Oligos’ precision and potential to open up the druggable space make them attractive modalities for drug developers, clinicians, and indeed patients. Furthermore, the chemistry behind oligonucleotides is crucial to their success as therapeutics. Oligo developers are therefore working on using chemistry to surmount the key challenges of this modality’s development. These include improving stability, delivery, immunogenicity, and off target effects.

We gathered together industry leaders for a half-day digital event, not only showcase the power of this emerging modality, but also unlock its full potential. This means going after the challenges which haunt oligonucleotide development: improving delivery, stability, and uptake. This eBook will see best practice solutions practiced by experts to tackle these difficulties.