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Tumbler: A Highly Customizable Antibody Optimization Suite

10 December 2024
On-demand presentation, presented by Michali Izhaky, Bioinformatics Scientist at Charles River . Sponsored by Charles River.
This presentation introduces the Tumbler™ platform, an advanced CDR-shuffling technology designed for comprehensive and customisable antibody optimisation. The platform supports a streamlined, single-step process for key modifications such as humanisation, affinity maturation, liability removal, and inducing cross-reactivity. Leveraging a library-based engineering approach, Tumbler™ enhances functional diversity and reveals critical insights into sequence-activity relationships, offering a versatile solution validated across a wide range of targets.
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Speaker Biographies

Michali Izhaky is a Bioinformatics Scientist on the Charles River Antibody Discovery Team and a Tumbler™ antibody engineering subject matter expert. She received her BS in Molecular, Cellular, and Developmental Biology from the University of Washington, and her Master's from the University of San Francisco where she studied Biotechnology and Data Science. She joined Distributed Bio in 2019, where she helped establish the Bioinformatics team and developed many of the informatics tools and processes which are integral components of our antibody engineering technologies. In addition to antibody engineering and computational immunology, her background lies in neurodegenerative disease and cognition, as well as vaccine design.

 

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