Power up RNA Therapeutics with Early Formulation Screening for Customized Lipid Nanoparticle Solutions
Getting new RNA therapeutics off the ground is challenging. With countless nanoparticle formulation options, researchers need a faster way to identify candidates that deliver nucleic acids efficiently and consistently. Traditional approaches are slow, resource-heavy, and often fail to highlight the best performers.
Early formulation screening changes the game. Using scalable, high-throughput tools like Sunscreen and Sunshine, Merck helps researchers explore a wide range of ionizable lipids, pinpoint top performers, and fine-tune key parameters—all while saving time and reducing complexity. This approach accelerates RNA drug development with customized LNP formulations that improve delivery efficiency and therapeutic outcomes.
Speaker Biographies
Johanna Simon, PhD, is heading the Formulation Discovery and Analytical Characterization team within the Early Formulation Screening Service at Merck Life Science, KGaA, Darmstadt. Her work focuses on the preclinical formulation development of custom LNPs for nucleic acid modalities. After receiving her Ph.D. in Chemistry, Johanna has continued her scientific career as a postdoctoral researcher with a focus on developing lipid-, polymer- and antibody-functionalized nanoparticles for targeted drug delivery in vivo. She has authored 50+ peer-reviewed articles in leading journals in the field of drug delivery sciences.
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