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The latest in immuno research, from the discovery & development of cell & antibody therapies through to omics-based approaches and clinical case studies

Top R&D Stories of 2023

Through captivating articles, insight pieces, and spotlight interviews, we delve into the remarkable innovations, breakthroughs, and scientific marvels that have defined the landscape of research over the past year.
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Therapeutic Modalities

Another Partnership from Takeda and F-Star Therapeutics to Look for Antibody-Based Therapies

The collaboration includes an upfront payment, milestone-dependent funds, and commercial royalties for F-star.
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Therapeutic Modalities

Immune Cell Types: Their Opportunities for Therapeutic Use in Oncology

An introduction to the various cell types in the immune system and the opportunities to harness them in immuno-oncology therapies.
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Translational & Preclinical Development

Transformative Partnership: Ozette Technologies and Umoja Biopharma Join Forces for Preclinical Studies

The collaboration aims to expand access to immunotherapies and advance the field of CAR T cell therapy.
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Therapeutic Modalities

William Coley, the Father of Cancer Immunotherapy and His Legacy

Despite facing criticism in his time, his work laid the foundation for modern immuno-oncology and his legacy continues through the Cancer Research Institute.
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Therapeutic Modalities

AstraZeneca and Daiichi Sankyo Share Results of IO Combination Therapy in Ib Clinical Trial

Preliminary results from phase Ib clinical trial, TROPION-Lung02, evaluating the antibody drug conjugate datopotamab deruxtecan in combination with pembrolizumab.
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Tumour Microenvironment

T Cell Atlas of Tumour Microenvironment Identifies Previously Unknown Cell State

The atlas provides valuable insights into T cell phenotypic states across various cancer types, paving the way for biomarker discovery and the development of improved therapeutic strategies.
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Therapeutic Modalities

Monoclonal Antibodies: Guided Missiles in the Battle Against Cancer and More

Monoclonal antibodies (mAbs) have emerged as highly promising and versatile treatments for various diseases, particularly cancer.
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Therapeutic Modalities

Identifying highly potent TNF-?-secreting T cells from blood samples in 7 hours using the Xdrop® double-emulsion droplet-based workflow

Bulk functional assays of immune cells miss highly potent cells within the population. This Xdrop workflow reveals highly potent TNF-?-secreting T cells in a human blood sample.
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Therapeutic Modalities

Xdrop® Encapsulate cells, DNA, and more with this benchtop instrument

Xdrop is a unique, user-friendly microfluidics instrument for preparing living mammalian or microbial cells, organelles, DNA, or other biological material for high-resolution downstream analyses.
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Therapeutic Modalities

Rapidly quantifying active killer cells using an Xdrop® single-cell format assay based on double-emulsion droplets

Bulk assays of killer cell activity mask the heterogeneity of the individual cells‘ actual cytotoxicity. This Xdrop single-cell format assay for quantifying natural killer cells reveals the active cells and enables their retrieval and expansion.
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Therapeutic Modalities

Revealing and retrieving highly potent IFN-? secretors using an Xdrop® single-cell format workflow based on double-emulsion droplets

Bulk functional assays of immune cells miss highly potent cells within the population. This Xdrop single-cell format workflow for IFN-? secretion assessment reveals these highly potent individual cells, enabling their retrieval and expansion.
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Therapeutic Modalities

Quantifying individual cells that secrete IFN-?, TNF-?, or both cytokines in a single-cell, drop®-based workflow

This Xdrop workflow enables rapid, multiplex quantification of the individual immune cells in a population that are secreting one or more cytokines. The results for single-cell format multiplex and singleplex assay concurred and were reproducible.
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