In-Depth

The In-Depth page consists of Insight Articles, Commentaries, C-level Q&As, Discussion Group Reports, and Survey Reports.

Insight Article
Explore the intricate world of the immunosuppressive tumor microenvironment (TME), a key player in cancer progression and treatment resistance
Edited by Guillaume Alonso |
08 December 2023
Tumour Microenvironment
Insight Article
Unpacking the potential of combining immuno-oncology and chemotherapy: understanding benefits, real-world impact, and addressing concerns.
Edited by Guillaume Alonso |
18 September 2023
Insight Article
Sourcing NK cells, expansion techniques, gene modification, quality control, safety, preservation, and delivery.
Edited by Tom Cohen |
22 August 2023
Therapeutic Modalities
Insight Article
The importance of validating hypotheses, understanding the biology of cancer progression, and utilising biomarkers in early screening to stratify populations and improve clinical endpoints.
Edited by Tom Cohen |
14 August 2023
Biomarkers in Immuno-Oncology
Insight Article
Unveiling advancements in preclinical immuno-oncology: Exploring humanized mouse models and human knock-in mice for targeted cancer therapies.
Edited by Tom Cohen |
02 August 2023
Translational & Preclinical Development
Insight Article
Looking at the past, present, and future of cancer vaccines. What are the reasons for past failings? And what's the next step for their development?
Edited by Tom Cohen |
11 May 2023
Therapeutic Modalities
Insight Article
Developing and validating IO biomarkers present challenges, such as working with challenging sample types, interpreting sequencing data, and integrating new technologies into the clinic.
Edited by Tom Cohen |
10 May 2023
Biomarkers in Immuno-Oncology
Insight Article
Insights on antigen-specific immunotherapy and the immunomodulatory functions of therapeutic chaperones at Immuno UK 2022.
Edited by Tom Cohen |
29 March 2023
Autoimmunity & Immunology
Insight Article
Oxford Global's panel discussion brings together expert scientists in the field of immunology and biomarker development.
Edited by Tom Cohen |
10 March 2023
Biomarkers in Immuno-Oncology
Insight Article
Our panel discussing combination therapeutics addresses challenges, modelling, and the importance of biomarkers.
Edited by Tom Cohen |
17 January 2023
Translational & Preclinical Development
Discussion Group Report
Our November Immuno-Oncology Discussion Group brought together experts in the field of oncolytic virus development to discuss engineering and translational strategies of the field
Edited by Tom Cohen |
03 January 2023
Therapeutic Modalities
Discussion Group Report
Are there too many opportunities in antibody-based immunotherapy? How do you choose your targets? How do you know when to kill a project?
Edited by Tom Cohen |
07 December 2022
Therapeutic Modalities
Insight Article
The panel at Immuno UK 2022 discuss the unique challenges that come with delivering immunotherapies to solid malignancies.
Edited by Tom Cohen |
22 November 2022
Translational & Preclinical Development
Commentary
As an alternative avenue for addressing difficult-to-treat cancers, viral immunotherapies hold significant promise. CAN-2409 is well-tolerated in phase II clinical trials in patients with prostate cancer, and new applications may be on the horizon.
10 November 2022
Therapeutic Modalities
Discussion Group Report
The tumour microenvironment is a critical target to immuno-oncologists. Our discussion group brings together authorities in targeting the TME.
Edited by Tom Cohen |
08 November 2022
Tumour Microenvironment
Commentary
Crescendo Biologics’ Humabody therapeutic has the potential to address a range of issues which arise when standard monoclonal antibodies target T cell receptors, thanks to their capacity to trigger conditional immune responses.
24 October 2022
Therapeutic Modalities
Insight Article
Our panel discussion brings together experts in immunology: discussing the key areas of autoimmunity, oncology, and COVID-19.
Edited by Tom Cohen |
18 October 2022
Autoimmunity & Immunology
Commentary
Synthetic immunity mediated by bispecific T Cell engagers may help to bypass immune escape posed by a lack of appropriate immunotherapeutic target expression. Bispecific T Cell engagers offer a solution to the issue of immune escape in cancer treatments, with the potential to become off-the-shelf therapeutics.
30 September 2022
Therapeutic Modalities
Insight Article
The targeted cancer therapy has made recent clinical and market breakthroughs, but what are the next hurdles for ADCs?
Edited by Tom Cohen |
23 September 2022
Therapeutic Modalities
Insight Article
Cell UK 2021 hosts experts in cell and immunotherapy working towards new diagnostic tools and therapies.
Edited by Tom Cohen |
12 September 2022
Therapeutic Modalities
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