Long Read DNA Sequencing has the potential to help diagnose several diseases and disorders. Recent advancements mean that long-read sequencing is no longer an expensive, low throughput, error-prone process.

In this Insight article, we explore some of the challenges and new innovations concerning spatial analysis of the tumour microenvironment. One of the key focuses for ongoing studies is the retention of spatial information, which enables researchers to identify distinct tumour subtypes.

In this Discussion Group Report, we investigate some recent applications of long- and short-read sequencing technologies. Continued improvements and advancements in the field mean sequencing errors are increasingly a thing of the past, while the portability of some new units makes them ideal for work in the field.