Antibody Discovery by Single B Cell Screening on Beacon®
Single B cell screening is a powerful and efficient strategy for generating antigen-specific monoclonal antibodies. Distinguished with fluorescence-activated B cell sorting, the Beacon® platform is based on plasma cell screening, making it easier to obtain antibody genes.
The Beacon® single-cell optofluidic system combines a unique optoelectro positioning (OEP) technology with novel microfluidic technology. It can be used to accurately select single cells on a chip, perform multiple single-cell assays, and export target cells based on specific results. The Beacon® optofluidic platform preserves the diversity of B cells, generating high-quality positive hits at an early stage of discovery and avoiding the loss of “good clones”.
The webinar will cover the following sections: 1. B cell differentiation and development; 2. Mainstream antibody screening platforms; 3. Beacon® platform; 4. Case studies using the Beacon® platform for antibody screening.
Key Learning Points:
1. Understanding the mechanisms, pros, and cons of different antibody screening platforms
2. Mechanisms and applications of the Beacon platform
3. Sino Biological's capacity using Beacon platform
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