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The latest in formulation & delivery research, from discovery and multi-omics approaches through to diagnostics development

Top R&D Stories of 2023

Through captivating articles, insight pieces, and spotlight interviews, we delve into the remarkable innovations, breakthroughs, and scientific marvels that have defined the landscape of research over the past year.
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Drug Formulation

Challenges in the Formulation of Biologics: Protein Aggregation, Safety, and Technology

Our panel discussion from Formulation UK 2021 highlights protein aggregation, safety, and novel technologies.
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Drug Delivery

Evaluating Closed System Drug-Transfer Devices

Using a combination of prevalent CSTDs with biologic molecules, we present a systematic approach to evaluate the risks and impact of CSTD to drug product quality, dose preparation, and dosing accuracy
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RNA Formulation & Delivery

From LNPs to AAVs: Overcoming RNA Delivery Challenges

RNA therapeutics have great potential, as evidenced by the success of Pfizer-BioNTech and Moderna’s COVID vaccines. One difficulty that may stunt their success lies in their delivery challenges.
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Drug Delivery

Key Strategies and Challenges for Lipid Nanoparticles

June’s Formulation discussion group focusses on nanoparticle development, safety, and optimisation.
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Drug Delivery

“Teaching Old Drugs New Tricks”: Repurposing Therapies Using Nanoparticle Delivery

Tackling problems in cancer resistance by turning to using already approved drugs in new ways.
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Drug Delivery

Exploring Ways of Crossing the Blood-Brain Barrier

The blood-brain barrier is one of the greatest challenges in drug delivery. The complex issue of getting active molecules out of the blood and into the brain is a task that requires innovative solutions. We discuss some of those methods here.
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Drug Delivery

Handle with Care: Continuous Delivery of Fragile Molecules

Peptides and proteins present unique challenges in long-acting sustained drug delivery. How is MedinCell innovating within this field to achieve a customisable platform for long-acting injectable delivery?
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RNA Formulation & Delivery

The Past 20 Years of RNA Therapeutics: COVID Vaccines and Beyond

Antonin de Fougerolles explains the development of LNPs which was fundamental in enabling COVID mRNA vaccines. Dr. de Fougerolles also talks on novel delivery methods such as GalNAc conjugates and exosomes.
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Inhaled Drug Delivery

Inhalation and Nasal Development and Manufacturing Services

Recipharm offers inhalation and nasal product development services in compliance with regulatory guidelines from the ICH, EMA and FDA.
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RNA Formulation & Delivery

Embracing The Power of RNA Therapeutics

Despite initial scepticism, RNA therapeutics have proven to be effective for a wide range of diseases and conditions. We are still in a pivotal era of the field, with many new and exciting research projects underway to discover novel applications.
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Inhaled Drug Delivery

How Are Inhaled Drugs Absorbed and Distributed in the Lungs?

Inhaled drugs are a viable means of targeting tobacco smoke-related diseases in the lungs: permeability is key to their successful delivery. This Commentary article explores the mechanisms by which drugs are delivered across cell membranes, as well as pertinent areas for present and future research.
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Bioanalysis

Bioanalysis: Predicting Protein Aggregation & Method Validation

Bioanalysis is an important tool to predict the stability and protein degradation in new pharmaceutical products. Can novel prediction methods provide an alternative to current methods?
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